High Quality P2NP CAS 705-60-2

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1-Phenyl-2-nitropropene, or simply phenyl-2-nitropropene, or P2NP, as it is commonly referred to, is a chemical compound from the aromatic group of compounds, with the formula C9H9NO2. It is a light-yellow crystalline solid with a distinct smell. Phenyl-2-nitropropene is used in the pharmaceutical industry to manufacture the drug Adderall, an amphetamine mixture used to treat ADHD and narcolepsy. P2NP and other similar nitrostyrenes are also employed in the clandestine manufacture of drugs of the amphetamine class, and are listed as drug precursors in many countries.

High Quality P2NP CAS 705-60-2

p2np cas 705-60-2

1. 1-Phenyl-2-nitropropene CAS 705-60-2 Product Information:

Product Name: 1-Phenyl-2-nitropropene
CAS NO: 705-60-2
Molecular Weight: 163.17
Molecular Formula:  C9H9NO2
Boiling Point: 263.0±9.0 °C at 760 mmHg
Melting point: 63-65 °C (lit.)
Density: 1.141±0.06 g/cm3(Predicted)
Storage 2-8°C
Solubility Soluble in DMSO
Appearance: Yellow cystaline powder
Applications: 1-phenyl-2-nitropropene is used in the production of pharmaceuticals, for instance, for drug Adderall, a drug used to treat ADHD and narcolepsy.

2. 1-Phenyl-2-nitropropene use

P2NP is used to produce a racemic amphetamine mixture, branded under the trade names Adderall and Mydayis, amongst others. In this case, the double bond is hydrogenated and the nitro group is reduced,[10] thus 1-phenyl-2-nitropropene becomes 1-phenyl-2-aminopropane, which is another name for amphetamine. Different reducing agents and solvents are used for this reaction, and various protocols exist. Often lithium aluminium hydride (LAH), aluminum amalgam or Raney nickel are used as a reducing agent, and the reaction is carried in a solvent like isopropyl alcohol or THF

3. 1-Phenyl-2-nitropropene  reduction(The following remarks are from reddit)

Is this a possible route? I understand the reaction mechanism behind this when it’s used on phenyl-2-propanone. And if this is possible a molar ratio of 1:2 would be required for the P2NP:HCl. Do you bees think this is possible?

you can start by reducing with sodium borohydride, do get the dihydro-P2NP (aka phenyl-2-nitropropane), and then reduce with zinc/hcl.Alternately, you can just use sodium borohydride plus copper chloride to yield the amphetamine all in one step: https://www.reddit.com/r/TheeHive/comments/epr3ew/novel_otc_onestep_routes_to/

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